Publikationen 2013


A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. Prandi S, Bromke M, Hübner S, Voigt A, Boehm U, Meyerhof W, Behrens M. PLoS One. 2013 Dec 18;8(12):e82820. doi: 10.1371/journal.pone.0082820. 

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells. Linxweiler M, Schorr S, Schäuble N, Jung M, Linxweiler J, Langer F, Schäfers HJ, Cavalié AZimmermann R, Greiner M. BMC Cancer. 2013 Dec 5;13:574. doi: 10.1186/1471-2407-13-574.


In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology. Pattu V, Halimani M, Ming M, Schirra C, Hahn U, Bzeih H, Chang HF, Weins L, Krause E, Rettig J. Front Immunol. 2013 Nov 27;4:411. doi: 10.3389/fimmu.2013.00411.

Super-resolution microscopy in studying neuroendocrine cell function. Bost A, Pasche M, Schirra C, Becherer UFront Neurosci. 2013 Nov 25;7:222. doi: 10.3389/fnins.2013.00222.

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer. Holzmann C, Kilch T, Kappel S, Armbrüster A, Jung V, Stöckle M, Bogeski I, Schwarz EC, Peinelt COncotarget. 2013 Nov;4(11):2096-107.

Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of gonadotrope cells. Savulescu D, Feng J, Ping YS, Mai, O, Boehm U, He B, O’Malley BW, Melamed P. Mol Endocrinol. 2013 Nov;27(11):1856-70. doi: 10.1210/me.2013-1210.

How ORAI and TRP channels interfere with each other: Interaction models and examples from the immune system and the skin. Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth MEur J Pharmacol. 2013 Nov 28. pii: S0014-2999(13)00882-0. doi: 10.1016/j.ejphar.2013.10.071. 

Genetic dissection of puberty in mice. Kumar D & Boehm UExp Physiol. 2013 Nov;98(11):1528-34. doi: 10.1113/expphysiol.2013.071928. 

Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Straub I, Krügel U, Mohr F, Teichert J, Rizun O, Konrad M, Oberwinkler J, Schaefer M. Mol Pharmacol. 2013 Nov;84(5):736-50. doi: 10.1124/mol.113.086843. 


The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a co chaperone and its substrate protein. Papic D, Elbaz-Alon Y, Koerdt SN, Leopold K, Worm D, Jung M, Schuldiner M, Rapaport D. Mol Cell Biol. 2013 Oct;33(20):4083-94. doi: 10.1128/MCB.00227-13

The CpG island in the murine Foxl2 proximal promoter is differentially methylated in primary and immortalized cells. Tran S, Wang Y, Lamba P, Zhou X, Boehm U, Bernard DJ. PLoS One. 2013 Oct 2;8(10):e76642. doi: 10.1371/journal.pone.0076642.

Deciphering dead-end docking of large dense core vesicles in bovine chromaffin cells. Hugo S, Dembla E, Halimani M, Matti U, Rettig JBecherer UJ Neurosci. 2013 Oct 23;33(43):17123-37. doi: 10.1523/JNEUROSCI.1589-13.2013.


Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering. Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB. J Neurosci. 2013 Sep 4;33(36):14417-30. doi: 10.1523/JNEUROSCI.1236-13.2013.


Membrane potential measurements of isolated neurons using a voltage-sensitive dye. Fairless R, Beck A, Kravchenko M, Williams SK, Wissenbach U, Diem R, Cavalié APLoS One. 2013;8(3):e58260. doi: 10.1371/journal.pone.0058260.

Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92). Haid D, Widmayer P, Voigt A, Chaudhari N, Boehm U, Breer H. Histochem Cell Biol. 2013 Aug;140(2):137-45. doi: 10.1007/s00418-013-1080-2.

Intracellular Na(+) and cardiac metabolism. Bay J, Kohlhaas M, Maack CJ Mol Cell Cardiol. 2013 Aug;61:20-7. doi: 10.1016/j.yjmcc.2013.05.010.

NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, Boehm U, Boerboom D, Bernard DJ. PLoS One. 2013;8(3):e59058. doi: 10.1371/journal.pone.0059058.

Global but not gonadotrope-specific disruption of bmal1 abolishes the luteinizing hormone surge without affecting ovulation. Chu A, Zhu L, Blum ID, Mai O, Leliavski A, Fahrenkrug J, Oster H, Boehm U, Storch KF. Endocrinology. 2013 Aug;154(8):2924-35. doi: 10.1210/en.2013-1080.

Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. de Croft S, Boehm U, Herbison AE (2013). Endocrinology. 2013 Aug;154(8):2750-60. doi: 10.1210/en.2013-1231.

Molecular regulation of CRAC channels and their role in lymphocyte function. Shaw PJ, Qu B, Hoth M, Feske S. Cell Mol Life Sci. 2013 Aug;70(15):2637-56. doi: 10.1007/s00018-012-1175-2.


Conserved gating elements in TRPC4 and TRPC5 channels. Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavalié A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V. J Biol Chem. 2013 Jul 5;288(27):19471-83. doi: 10.1074/jbc.M113.478305.

Myocardial energetics in heart failure. Nickel A, Löffler J, Maack CBasic Res Cardiol. 2013 Jul;108(4):358. doi: 10.1007/s00395-013-0358-9.

Different munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause ERettig JTraffic. 2013 Jul;14(7):798-809. doi: 10.1111/tra.12074.

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M,Trotter J, Krämer-Albers EM. PLoS Biol. 2013 Jul;11(7):e1001604. doi: 10.1371/journal.pbio.1001604.

Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells. Schwarz EC, Qu B, Hoth MBiochim Biophys Acta. 2013 Jul;1833(7):1603-11. doi: 10.1016/j.bbamcr.2012.11.016.


The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG. Fecher-Trost C, Wissenbach U, Beck A, Schalkowsky P, Stoerger C, Doerr J, Dembek A, Simon-Thomas M, Weber A, Wollenberg P, Ruppert T, Middendorff R, Maurer HH, Flockerzi VJ Biol Chem. 2013 Jun 7;288(23):16629-44. doi: 10.1074/jbc.M113.469726.

Estrous cycle plasticity in the hyperpolarization-activated current ih is mediated by circulating 17β-estradiol in preoptic area kisspeptin neurons. Piet R, Boehm U, Herbison AE. J Neurosci. 2013 Jun 26;33(26):10828-39. doi: 10.1523/JNEUROSCI.1021-13.2013.

A Local, Periactive Zone Endocytic Machinery at Photoreceptor Synapses in Close Vicinity to Synaptic Ribbons. Wahl S, Katiyar R, Schmitz FJ Neurosci. 2013 Jun 19;33(25):10278-300. doi: 10.1523/JNEUROSCI.5048-12.2013.

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1B(high) Cells. Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SEKrause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M. Cancer Cell. 2013 Jun 10;23(6):811-25. doi: 10.1016/j.ccr.2013.05.003.

Genetic background affects human glial fibrillary acidic protein promoter activity. Bai X, Saab AS, Huang W, Hoberg IK, Kirchhoff F, Scheller A. PLoS One. 2013 Jun 24;8(6):e66873. doi: 10.1371/journal.pone.0066873.

Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation. Wang J, Wagner-Britz L, Bogdanova A, Ruppenthal S, Wiesen K, Kaiser E, Tian Q, Krause E, Bernhardt I, Lipp P, Philipp SE, Kaestner L. PLoS One. 2013 Jun 28;8(6):e67697. doi: 10.1371/journal.pone.0067697.

The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice. Arakawa H, Kelliher KR, Zufall F, Munger SD. Chem Senses. 2013 Jun;38(5):391-7. doi: 10.1093/chemse/bjt015.

Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure. Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi VPhilipp SE, Birnbaumer L, Freichel M, Poole AW. Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.


Calcium release microdomains and mitochondria. Kohlhaas M, Maack CCardiovasc Res. 2013 May 1;98(2):259-68. doi: 10.1093/cvr/cvt032.

Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair Cells. Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Bernd Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M. J Neurosci. 2013 May 29;33(22):9508-19. doi: 10.1523/JNEUROSCI.5689-12.2013.

Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. Foster SR, Porrello ER, Purdue B, Chan HW, Voigt A, Frenzel S, Hannan RD, Moritz KM, Simmons DG, Molenaar P, Roura E, Boehm U, Meyerhof W, Thomas WG. PLoS One. 2013 May 15;8(5):e64579. doi: 10.1371/journal.pone.0064579.

Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells. Schmidt T, Schirra C, Matti U, Stevens DR, Rettig JCell Calcium. 2013 May 29. doi:pii: S0143-4160(13)00070-5. 10.1016/j.ceca.2013.05.003.


Taste responses in mice lacking taste receptor subunit T1R1. Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hübner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y. J Physiol. 2013 Apr 1;591(Pt 7):1967-85. doi: 10.1113/jphysiol.2012.236604.

Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Straub I, Mohr F, Stab J, Konrad M, Philipp SEOberwinkler J, Schaefer M. Br J Pharmacol. 2013 Apr;168(8):1835-50. doi: 10.1111/bph.12076.


Impaired Fertility and FSH Synthesis in Gonadotrope-Specific Foxl2 Knockout Mice. Tran S, Zhou X, Lafleur C, Calderon MJ, Ellsworth BS, Kimmins S, Boehm U, Treier M, Boerboom D, Bernard DJ. Mol Endocrinol. 2013 Mar;27(3):407-21. doi: 10.1210/me.2012-1286.

HDAC4 controls histone methylation in response to elevated cardiac load. Hohl M, Wagner M, Reil JC, Müller SA, Tauchnitz M, Zimmer AM, Lehmann LH, Thiel G, Böhm M, Backs J, Maack CJ Clin Invest. 2013 Mar 1;123(3):1359-70. doi: 10.1172/JCI61084.

Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells. Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X. Curr Mol Med. 2013 Mar;13(3):417-28.

Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Sturm T, Leinders-Zufall T, Maček B, Walzer M, Jung S, Pömmerl B, Stevanović S, Zufall F, Overath P, Rammensee HG. Nat Commun. 2013 Mar 19;4:1616. doi: 10.1038/ncomms2610. 


ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt CNiemeyer BA, Valverde MA, Vicente R. Hum Mol Genet. 2013 Feb 1;22(3):519-30. doi: 10.1093/hmg/dds450.

SR and mitochondria: Calcium cross-talk between kissing cousins. Dorn GW, 2nd, Maack CJ Mol Cell Cardiol. 2013 Feb;55:42-9. doi: 10.1016/j.yjmcc.2012.07.015.

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion. Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Chang HF, Guzman R, Olausson J, Freichel MSchmitz F, Pasche M, Becherer UBruns DRettig JNat Commun. 2013;4:1439. doi: 10.1038/ncomms2467.

Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Mol Pharmacol. 2013 Feb;83(2):429-38. doi: 10.1124/mol.112.082271.


Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1. Kilch T, Alansary D, Peglow M, Dörr K, Rychkov G, Rieger H, Peinelt C, Niemeyer BA. J Biol Chem. 2013 Jan 18;288(3):1653-64. doi: 10.1074/jbc.M112.417246. 

RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization. Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker A, Schoch S. J Neurosci. 2013 Jan 9;33(2):824-39. doi: 10.1523/JNEUROSCI.2229-12.2013.

Microglia: new roles for the synaptic stripper. Kettenmann H, Kirchhoff F, Verkhratsky A. Neuron. 2013 Jan 9;77(1):10-8. doi: 10.1016/j.neuron.2012.12.023.


The Neglected CRAC Proteins: Orai2, Orai3, and STIM2. Hoth MNiemeyer BACurr Top Membr. 2013;71:237-71. doi: 10.1016/B978-0-12-407870-3.00010-X.

TMEM2 proteins regulate amylase secretion from pancreatic acinar cells in mice. Kriebs U, Bach A, Wissenbach U, Mannebach S, Flockerzi VWeissgerber PLipp P, Tsvilovskyy V, Freichel M (2013) Naunyn-Schmiedeberg’s Arch Pharmacol. 2013 177, Suppl. 1: 44-45.