Publications 2020
December
Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function. Vilas-Boas EA, Karabacz N, Marsiglio-Librais GN, Valle MMR, Nalbach L, Ampofo E, Morgan B, Carpinelli AR, Roma LP. Pharmacol Rep. 2020 Dec; 72(6):1725-1737. doi: 10.1007/s43440-020-00101-6. Epub 2020 Apr 9. PMID: 32274767.
November
Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets. Vilas-Boas EA, Nalbach L, Ampofo E, Lucena CF, Naudet L, Ortis F, Carpinelli AR, Morgan B, Roma LP. Free Radic Biol Med. 2020 Nov 27;162:1-13. doi: 10.1016/j.freeradbiomed.2020.11.023. Online ahead of print. PMID: 33249137
September
TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61-channel. Klein MC, Lerner M, Nguyen D, Pfeffer S, Dudek J, Förster F, Helms V, Lang S, Zimmermann R. Channels (Austin). 2020 Dec; 14(1):28-44. doi: 10.1080/19336950.2020.1724759. PMID: 32013668.
Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells. Nunes Marsiglio-Librais G, Aparecida Vilas-Boas E, Carlein C, Hoffmann MDA, Roma LP, Carpinelli AR. Redox Rep. 2020 Dec;25(1):41-50. doi: 10.1080/13510002.2020.1757877. PMID: 32354273.
July
Prion Protein Translocation Mechanism Revealed by Pulling Force Studies. Kriegler T, Lang S, Notari L, Hessa T.J Mol Biol. 2020 Jul 24;432(16):4447-4465. doi: 10.1016/j.jmb.2020.05.022. Epub 2020 Jun 2.PMID: 32502491.
Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse. Chitirala P, Chang HF, Martzloff P, Harenberg C, Ravichandran K, Abdulreda MH, Berggren PO, Krause E, Schirra C, Leinders-Zufall T, Benseler F, Brose N, Rettig J. Elife. 2020 Jul 22;9:e58065. doi: 10.7554/eLife.58065.PMID: 32696761.
Juni
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D. Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907. PMID: 32579112; PMCID: PMC7338050.
May
Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes. Sleiman M, Stevens DR, Chitirala P, Rettig J. Front Immunol. 2020 May 29;11:1080. doi: 10.3389/fimmu.2020.01080. eCollection 2020. PMID: 32547563.
Role of V-ATPase a3-Subunit in Mouse CTL Function. Chitirala P, Ravichandran K, Schirra C, Chang HF, Krause E, Kazmaier U, Lauterbach MA, Rettig J. J Immunol. 2020 May 15;204(10):2818-2828. doi: 10.4049/jimmunol.1901536. Epub 2020 Apr 8. PMID: 32269094.
14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity.Duscha K, Martins Rodrigues C, Müller M, Wartenberg R, Fliegel L, Deitmer JW, Jung M, Zimmermann R, Neuhaus HE. Int J Mol Sci. 2020 May 8;21(9):3334. doi: 10.3390/ijms21093334. PMID: 32397251; PMCID: PMC7246916.
April
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W. Immunity. 2020 Apr 14;52(4):683-699.e11. doi: 10.1016/j.immuni.2020.03.005. PMID: 32294408.
Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses. Dembla E, Dembla M, Maxeiner S, Schmitz F. Sci Rep. 2020 Apr 6;10(1):5957. doi: 10.1038/s41598-020-62734-0. PMID: 32249787.
Various Stages of Immune Synapse Formation Are Differently Dependent on the Strength of the TCR Stimulus. Estl M, Blatt P, Li X, Becherer U, Chang HF, Rettig J, Pattu V. Int J Mol Sci. 2020 Apr 2;21(7):2475. doi: 10.3390/ijms21072475. PMID: 32252488.
March
Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import. Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R. FEBS J. 2020 Mar 4. doi: 10.1111/febs.15274. Online ahead of print. PMID: 32133789.
Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells. Roma LP, Jonas JC. J Mol Biol. 2020 Mar 6;432(5):1461-1493. doi: 10.1016/j.jmb.2019.10.012. Epub 2019 Oct 18. PMID: 31634466
Mitochondria Do Not Survive Calcium Overload During Transplantation. Bertero E, O'Rourke B, Maack C, Circ Res. 2020 Mar 13;126(6):784-786. doi: 10.1161/CIRCRESAHA.119.316291. Epub 2020 Feb 6. PMID: 32078444.
February
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates. Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL. Sci Rep. 2020 Feb 25;10(1):3412. doi: 10.1038/s41598-020-60118-y. PMID: 32098978 Free.
January
The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments. Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N. BMC Biol. 2020 Jan 6;18(1):2. doi: 10.1186/s12915-019-0733-6. PMID: 31907035.
Gαi2+ vomeronasal neurons govern the initial outcome of an acute social competition. Pallé A, Montero M, Fernández S, Tezanos P, de Las Heras JA, Luskey V, Birnbaumer L, Zufall F, Chamero P, Trejo JL. Sci Rep. 2020 Jan 21;10(1):894. doi: 10.1038/s41598-020-57765-6. PMID: 31965032.
RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells. Ortner NJ, Pinggera A, Hofer NT, Siller A, Brandt N, Raffeiner A, Vilusic K, Lang I, Blum K, Obermair GJ, Stefan E, Engel J, Striessnig J. Pflugers Arch. 2020 Jan;472(1):3-25. doi: 10.1007/s00424-019-02338-4. Epub 2019 Dec 17. PMID: 31848688.