Publications 2014


Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegenerationSynofzik M, Haack TB, Kopajtich R, Gorza M, Rapoport D, Greiner M, Schönfeld C, Freiberg C, Schorr S, Holl RW, Gonzalez MA, Fritsche  A, Fallier-Becker P, Zimmermann R, Strom TM, Meitinger T, Züchner S, Schüle R, Schöls L, Prokisch H. Am J Hum Genet. 2014 Dec 4;95(6):689-97. doi: 10.1016/j.ajhg.2014.10.013.

Co-chaperones of the mammalian endoplasmic reticulum. Melnyk A, Rieger H, Zimmermann R. Subcell Biochem. 2015;78:179-200. doi: 10.1007/978-3-319-11731-7_9.

Protein transport into the human ER and related diseases, Sec61-channelopathies. Haßdenteufel S, Klein MC, Melnyk A, Zimmermann R. Biochem Cell Biol. 2014 Dec;92(6):499-509. doi: 10.1139/bcb-2014-0043.

Kisspeptin-cell specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility. Beymer M, Negrón AL, Yu G, Wu S, Mayer C, Lin RZ, Boehm U, Acosta-Martinez M. Am J Physiol Endocrinol MetabAm J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E969-82. doi: 10.1152/ajpendo.00385.2014.

Conditional genetic transsynaptic tracing in the embryonic mouse brain. Kumar D & Boehm UJ Vis Exp. 2014 Dec 22;(94). doi: 10.3791/52487.

Protonophore properties of hyperforin are essential for its pharmacological activity. Sell TS, Belkacemi T, Flockerzi V, Beck A. Sci Rep. 2014 Dec 16;4:7500. doi: 10.1038/srep07500.

The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins. Stoerger C, Flockerzi V. Biochem Cell Biol. 2014 Dec;92(6):441-8. doi: 10.1139/bcb-2014-0063.


Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. Nguyen Truong CQ, Nestvogel D, Ratai O, Schirra C, Stevens DR, Brose N, Rhee J, Rettig J. Cell Rep. 2014 Nov 6;9(3):902-9. doi: 10.1016/j.celrep.2014.09.050. 

Altered synaptic transmission at olfactory and vomeronasal nerve terminals in mice lacking N-type calcium channel Cav2.2. Weiss J, Pyrski M, Weissgerber P, Zufall F. Eur J Neurosci. 2014 Nov;40(10):3422-35. doi: 10.1111/ejn.12713.


Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide. Ermakova YG, Bilan DS, Matlashov ME, Mishina NM, Markvicheva KN, Subach OM, Subach FV, Bogeski I, Hoth M, Enikolopov G, Belousov VV. Nat Commun. 2014 Oct 21;5:5222. doi: 10.1038/ncomms6222.


Secretion and immunogenicity of the meningioma-associated antigen TXNDC16. Harz C, Ludwig N, Lang S, Werner TV, Galata V, Backes C, Schmitt K, Nickels R, Krause E, Jung M, Rettig J, Keller A, Menger M, Zimmermann R, Meese E. J Immunol. 2014 Sep 15;193(6):3146-54. doi: 10.4049/jimmunol.1303098.

Differential synaptic distribution of the scaffold proteins Cask and Caskin1 in the bovine retina. Anjum R, Ayoubian H, Schmitz FMol Cell Neurosci. 2014 Sep;62:19-29. doi: 10.1016/j.mcn.2014.08.004.

Regulation of endogenous and heterologous Ca2+ release-activated Ca2+ currents by pH.Beck A, Fleig A, Penner R, Peinelt C. Cell Calcium. 2014 Sep;56(3):235-43. doi: 10.1016/j.ceca.2014.07.011.


Mitochondrial reactive oxygen species production and elimination. Nickel A, Kohlhaas M, Maack CJ Mol Cell Cardiol. 2014 Aug;73:26-33. doi: 10.1016/j.yjmcc.2014.03.011.

Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. Fortin J, Boehm U, Deng CX, Treier M, Bernard DJ. FASEB J. 2014 Aug;28(8):3396-410. doi: 10.1096/fj.14-249532.

Genetic control of astrocyte function in neural circuits. Jahn HM, Scheller A, Kirchhoff F.Front Cell Neurosci. 2015 Aug 17;9:310. doi: 10.3389/fncel.2015.00310.


Evidence that insulin signalling in GnRH and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. Evans MC, Rizwan M, Mayer C, Boehm U, Anderson GM. J Neuroendocrinol. 2014 Jul;26(7):468-79. doi: 10.1111/jne.12166.

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Tian J, Thakur DP, Lu Y, Zhu Y, Freichel MFlockerzi V, Zhu MX. Pflugers Arch. 2014 Jul;466(7):1301-16.

Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes. Aziz R, Beymer M, Negron A, Yu G, Rosati B, McKinnon D, Fikuda M, Lin R, Mayer C, Boehm U, Acosta-Martínez. J Neuroendocrinol. 2014 Jul;26(7):426-38. doi: 10.1111/jne.12163.


Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F. Glia. 2014 Jun;62(6):896-913. doi: 10.1002/glia.22648.

A simple, economic, time-resolved killing assay. Kummerow C, Schwarz EC, Bufe B, Zufall FHoth M, Qu B. Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518.


A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein G(alpha)oOboti L, Pérez-Gómez A, Keller M, Jacobi E, Birnbaumer L, Leinders-Zufall TZufall F, Chamero P. BMC Biol. 2014 May 2;12:31. doi: 10.1186/1741-7007-12-31.

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Stanisz H, Saul S, Müller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I. Pigment Cell Melanoma Res. 2014 May;27(3):442-53. doi: 10.1111/pcmr.12222.


Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein. Zimmermann J, Latta L, Beck A, Leidinger P, Fecher-Trost C, Schlenstedt G, Meese E, Wissenbach U, Flockerzi VJ Biol Chem. 2014 Apr 4;289(14):9766-80. doi: 10.1074/jbc.M114.557066.

ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis. Dembla M, Wahl S, Katiyar R, Schmitz FJ Neurosci. 2014 Apr 9;34(15):5245-60. doi: 10.1523/JNEUROSCI.3837-13.2014.

A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. Leinders-Zufall T, Ishii T, Chamero P, Hendrix P, Oboti L, Schmid A, Kircher S, Pyrski M, Akiyoshi S, Khan M, Vaes E, Zufall F, Mombaerts P. J Neurosci. 2014 Apr 9;34(15):5121-33. doi: 10.1523/JNEUROSCI.0186-14.2014.


Contribution of calcium-conducting channels to the transport of zinc ions. Bouron A, Oberwinkler JPflugers Arch. 2014 Mar;466(3):381-7. doi: 10.1007/s00424-013-1295-z.

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamicsDhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam PK, Bost A, Schirra C, Rettig J, Reim K, Brose N, Mohrmann R, Bruns DJ Cell Biol. 2014 Mar 31;204(7):1123-40. doi: 10.1083/jcb.201311085.

Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. Kumar D, Freese M, Drexler D, Hermans-Borgmeyer I, Marquardt A, Boehm UJ Neurosci. 2014 Mar 5;34(10):3756-66. doi: 10.1523/JNEUROSCI.5123-13.2014.

Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells. Fortin J, Boehm U, Weinstein MB, Graff JM, Bernard DJ. FASEB J. 2014 Mar;28(3):1474-85. doi: 10.1096/fj.13-237818.


Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes. Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung MBecherer UKrause EHoth M, Schwarz EC, Rettig JEur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011.

Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses. Schmitz F. Front Mol Neurosci. 2014 Feb 6;7:3. doi: 10.3389/fnmol.2014.00003.

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels. Drews A, Mohr F, Rizun O, Wagner TF, Dembla S, Rudolph S, Lambert S, Konrad M, Philipp SE, Behrendt M, Marchais-Oberwinkler S, Covey DF, Oberwinkler JBr J Pharmacol. 2014 Feb;171(4):1019-32. doi: 10.1111/bph.12521.


Interaction of Pseudomonas aeruginosa Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum. Schäuble N, Cavalié AZimmermann RJung MChannels (Austin). 2014 Jan-Feb;8(1):76-83. doi: 10.4161/chan.26526. 

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression. Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE. J Neurosci. 2014 Jan 22;34(4):1446-61. doi: 10.1523/JNEUROSCI.3935-13.2014.

Structure of the mammalian Oligosaccharyltransferase in the native ER protein translocon. Pfeffer S, Dudek J, Gogala M, Schorr S, Linxweiler J, Lang S, Beckmann R, Zimmermann R, Förster F. Nat Commun. 2014 Jan 10;5:3072. doi: 10.1038/ncomms4072.

α2δ3 Is Essential for Normal Structure and Function of Auditory Nerve Synapses and Is a Novel Candidate for Auditory Processing Disorders. Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel JJ Neurosci. 2014 Jan 8;34(2):434-45. doi: 10.1523/JNEUROSCI.3085-13.2014.

Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice. Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londoño JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R. Circ Res. 2014 Jan 17;114(2):283-94. doi: 10.1161/CIRCRESAHA.114.302835. 

L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Hofmann F, Flockerzi V, Kahl S, Wegener JW. Physiol Rev. 2014 Jan;94(1):303-26. doi: 10.1152/physrev.00016.2013.

A novel Pex14 interacting site of human Pex5 is critical for matrix protein import into peroxisomes. Neuhaus A, Kooshapur H, Wolf J, Meyer HN, Madl T, Saidowsky J, Hambruch E, Lassam A, Jung M, Sattler M, Schliebs W, Erdmann R. J Biol Chem. 2014 Jan 3;289(1):437-48. doi: 10.1074/jbc.M113.499707.


What do we really know and what do we need to know: some controversies, perspectives, and surprises. Nilius B, Flockerzi VHandb Exp Pharmacol. 2014;223:1239-80. doi: 10.1007/978-3-319-05161-1_20.

TRPs: truly remarkable proteins. Flockerzi V, Nilius B. Handb Exp Pharmacol. 2014;222:1-12. doi: 10.1007/978-3-642-54215-2_1.

TRPV6 channels. Fecher-Trost C, Weissgerber P, Wissenbach U. Handb Exp Pharmacol. 2014;222:359-84. doi: 10.1007/978-3-642-54215-2_14.

TRPM3. Oberwinkler JPhilipp SEHandb Exp Pharmacol. 2014;222:427-59. doi: 10.1007/978-3-642-54215-2_17.

TRP channels in reproductive (neuro)endocrinology. Leinders-Zufall T & Boehm UHandb Exp Pharmacol. 2014;223:1107-1118. doi: 10.1007/978-3-319-05161-1_20.

Topology and subcellular localization of TMEM2, a transmembrane protein regulating amylase secretion from acinar cells. Bach A, Kriebs U, Wissenbach U, Jha A, Mannebach-Götz S, Zimmermann K, Vogt D, Scholz A, Muallem S, Pfeifer A, Weissgerber PFlockerzi VLipp P, Tsvilovskyy V, Freichel MNaunyn-Schmiedeberg’s Arch Pharmacol. 2014 100, Suppl. 1:26.