Project A18 - Ulrich Boehm

Propagation of GnRH-induced Ca2+ signals in the pituitary gland 

Gonadotropes in the anterior pituitary are the link between brain and gonads and control mammalian reproduction. Gonadotrope function is regulated by Ca2+ signals.

We want to analyze the dynamics of this regulation in intact tissue to understand how the gonadotrope cell network adapts hormone-release to different reproductive stages.

Towards this goal we have generated genetically modified mice in which gonadotropes specifically express different fluorescent markers and optogenetic tools.

This allows us to study the propagation of Ca2+ signals in gonadotropes in situ.