Project A13 - Christoph Maack

NO synthase and mitochondrial redox state

In chronic heart failure, defects of cardiomyocyte Na+ and Ca2+ homeostasis cause an energetic deficit and oxidative stress.

This is related to deficient mitochondrial Ca2+ uptake, which causes reduced stimulation of Krebs cycle induced production of NADH (for the respiratory chain) and NADPH (for antioxidative enzymes).

Here, we investigate the role of NO, which is produced by Ca2+- and NADPH-dependent NO-synthases, for the regulation of oxidative phosphorylation, redox state and reactive oxygen species.