Mitochondrial membrane scaffolds as central nodes of intracellular Ca²⁺ signaling

Mitochondria regulate intracellular Ca²⁺ homeostasis and depend on Ca²⁺ uptake for optimal bioenergetic performance. We study the role of the mitochondrial contact site and cristae organizing system (MICOS), a major determinant of mitochondrial membrane architecture, for Ca²⁺ handling.

Based on our finding that MICOS is required for correct positioning of Ca²⁺ transporters within mitochondria, we propose that MICOS and its interacting partners, like SLC25A46, act as central coordinators of mitochondrial membrane protein sorting to safeguard efficient Ca²⁺ cycling.