Project A2 - Barbara Niemeyer
Physiological functions of novel STIM1 and STIM2 splice variants
Store-operated calcium entry (SOCE) is a ubiquitous mechanism regulating Ca2+ homeostasis. Functional and active Ca2+ release-activated Ca2+ (CRAC) channels are composed of a complex of the pore-forming Orai (Orai1-3) subunits within the plasma membrane in close apposition to their ER-localized activators STIM1 and STIM2.
We want to understand how individual cell-types tune SOCE to suit the spatial and temporal requirements of particular functions by splicing the activator molecules STIM1 and STIM2.

Saarland University
Institute of Physiologie
CIPMM, Building 48
66421 Homburg
Germany