Project A19 - Peter Lipp

The role of Gq-dependent signaling for pacemaking, impulse propagation and contractility of the heart

A novel algorithmic approach, CaCLEAN, provides functional 3D maps of excitation-contraction coupling couplons in beating cardiomyocytes and thus further enlightens remodeling processes in cardiac diseases. In the heart, specific in vivo activation of Gq-coupled signaling via design receptors (DREADD) alters impulse-generation and -propagation and coordinated delivery.

Thus, Gq-coupled signaling directly modifies cardiac electrophysiology such as intercellular communication. DREADDs will advance our understanding of the dynamic modulatory impact of Gq signaling in the in vivo heart.