Project A19 - Peter Lipp
The role of Gq-dependent signaling for pacemaking, impulse propagation and contractility of the heart
A novel algorithmic approach, CaCLEAN, provides functional 3D maps of excitation-contraction coupling couplons in beating cardiomyocytes and thus further enlightens remodeling processes in cardiac diseases. In the heart, specific in vivo activation of Gq-coupled signaling via design receptors (DREADD) alters impulse-generation and -propagation and coordinated delivery.
Thus, Gq-coupled signaling directly modifies cardiac electrophysiology such as intercellular communication. DREADDs will advance our understanding of the dynamic modulatory impact of Gq signaling in the in vivo heart.
Institute of Molecular Cell Biology/ PZMS