Ca2+- dependent CTL and NK cell cytotoxicity
Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells form intimate contacts with tumor cells. We have shown that CTL and NK cells kill tumor cells most efficiently during contact formation at a surprisingly low cytosolic Ca2+ concentration.
We will analyze the molecular mechanisms of this process. Considering the importance of CTL and NK cells in cellular immune therapy of cancer, we will screen natural compounds for their ability to modulate Ca2+-dependent cytotoxicity. Finally, we will analyze the role of Ca2+ in human cytotoxicity diseases