Ca2+-Signale:
Molekulare Mechanismen und Integrative Funktionen
Sonder­forschungs­bereich 894

Publikationen 2012

Dezember

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA. Nat Med. 2012 Dec;18(12):1805-11. doi: 10.1038/nm.3015.

November

Combined two-photon laser-scanning microscopy and spectral microCT X-ray imaging to characterize the cellularsignature and evolution of microstroke foci. Kirchhoff F, Debarbieux F, Kronland-Martinet C, Cojocaru GR, Popa-Wagner A. Rom J Morphol Embryol. 2012;53(3 Suppl):671-5.

Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles. Borisovska M, Schwarz YN, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu SW, Kesavan J, Mohrmann R, Böckmann RA, Bruns DJ Neurosci. 2012 Nov 7;32(45):15983-97. doi: 10.1523/JNEUROSCI.6282-11.2012.

Oktober

Gonadotrope plasticity at cellular and population levels. Alim Z, Hartshorn C, Mai O, Stitt I, Clay C, Tobet S, Boehm U. Endocrinology. 2012 Oct;153(10):4729-39.

From genes to social communication: molecular sensing by the vomeronasal organ. Chamero P, Leinders-Zufall TZufall FTrends Neurosci. 2012 Oct;35(10):597-606. doi: 10.1016/j.tins.2012.04.011.

Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels. Fruehwald J, Camacho Londono J, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler JPhilipp SEJ Biol Chem. 2012 Oct 26;287(44):36663-72. doi: 10.1074/jbc.M112.396663.

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Woudenberg-Vrenken TE, Lameris AL, Weissgerber P, Olausson J, Flockerzi V, Bindels RJ, Freichel M, Hoenderop JG. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G879-85. doi: 10.1152/ajpgi.00089.2012.

September

ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai. Bogeski I, Kilch T, Niemeyer BAJ Physiol. 2012 Sep 1;590(Pt 17):4193-200. doi: 10.1113/jphysiol.2012.230565.

Formyl peptide receptors from immune and vomeronasal system exhibit distinct agonist properties. Bufe B, Schumann T, Zufall FJ Biol Chem. 2012 Sep 28;287(40):33644-55.

Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. Kurt S, Sausbier M, Rüttiger L, Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H. FASEB J. 2012 Sep;26(9):3834-43. doi: 10.1096/fj.11-200535.

Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca2+ crosstalk. Chen Y, Csordas G, Jowdy C, Schneider TG, Csordas N, Wang W, Liu Y, Kohlhaas M, Meiser M, Bergem S, Nerbonne JM, Dorn GW, 2nd, Maack CCirc Res. 2012 Sept 14;111(7):863-875. doi: 10.1161/CIRCRESAHA.112.266585.

Regulated exocytosis in chromaffin cells and cytotoxic T lymphocytes: How similar are they? Becherer U, Medart MR, Schirra C, Krause E, Stevens D, Rettig JCell Calcium. 2012 Sep-Oct;52(3-4):303-12. doi: 10.1016/j.ceca.2012.04.002. 

Link Between Pain and Olfaction in an Inherited Sodium Channelopathy. Zufall F, Pyrski M, Weiss J, Leinders-Zufall TArch Neurol. 2012 Sep;69(9):1119-23. doi: 10.1001/archneurol.2012.21.

August

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan O, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié AZimmermann REMBO J. 2012 Aug 1;31(15):3282-96. doi: 10.1038/emboj.2012.189.

Can we see PIP(3) and hydrogen peroxide with a single probe? Mishina NM, Bogeski I, Bolotin DA, Hoth MNiemeyer BA, Schultz C, Zagaynova EV, Lukyanov S, Belousov VV. Antioxid Redox Signal. 2012 Aug 1;17(3):505-12. doi: 10.1089/ars.2012.4574. 

Imaging Calcium Responses in GFP-tagged Neurons of Hypothalamic Mouse Brain Slices. Schauer C, Leinders-Zufall TJ Vis Exp. 2012 Aug 24;(66):e4213. doi: 10.3791/4213.

Bergmann glial AMPA receptors are required for fine motor coordination. Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff FScience. 2012 Aug 10;337(6095):749-53. doi: 10.1126/science.1221140.

Juli

Docking of LDCVs is modulated by lower intracellular [Ca2+] than priming. Pasche M, Matti U, Hof D, Rettig JBecherer UPLoS One. 2012;7(5):e36416. doi: 10.1371/journal.pone.0036416.

Mitochondrial dynamics and their impact on T cell function. Quintana A, Hoth MCell Calcium. 2012 Jul;52(1):57-63. doi: 10.1016/j.ceca.2012.02.005.

Juni

The Role of TRP Proteins in Mast Cells. Freichel M, Almering J, Tsvilovskyy V. Front Immunol. 2012 Jun 12;3:150. doi: 10.3389/fimmu.2012.00150. 

Mammalian-Specific OR37 Receptors Are Differentially Activated by Distinct Odorous Fatty Aldehydes. Bautze V, Bär R, Fissler B, Trapp M, Schmidt D, Beifuss U, Bufe B, Zufall F, Breer H, Strotmann. Chem Senses. 2012 Jun;37(5):479-93. doi: 10.1093/chemse/bjr130.

Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias. Molina CE, Leroy J, Richter W, Xie M, Scheitrum C, Lee IO, Maack C, Rucker-Martin C, Donzeau-Gouge P, Verde I, Llach A, Hove-Madsen L, Conti M, Vandecasteele G, Fischmeister R. J Am Coll Cardiol. 2012 Jun 12;59(24):2182-90. doi: 10.1016/j.jacc.2012.01.060.

Mai

Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. J Biol Chem. 2012 May 25;287(22):17930-41. doi: 10.1074/jbc.M111.328286. 

Dissecting the role of G-protein-coupled receptor kinase 2 for excitation-contraction coupling. Maack CCirculation. 2012 May 1;125(17):2054-6. doi: 10.1161/CIRCULATIONAHA.112.109389.

ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt CHoth MNiemeyer BA, Vogt T, Bogeski I. J Invest Dermatol. 2012 May;132(5):1443-51. doi: 10.1038/jid.2011.478.

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN. Open Biol. 2012 May;2(5):120068. doi: 10.1098/rsob.120068.

The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice. van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG, Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP. J Cell Physiol. 2012 May;227(5):1951-9. doi: 10.1002/jcp.22923.

April

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause ERettig J, Somlo S, Zimmermann R, Dudek J. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69. doi: 10.1242/jcs.096727.

On the scent of mitochondrial calcium. Zufall FNat Neurosci. 2012 Apr 25;15(5):653-4. doi: 10.1038/nn.3090.

Preclinical retinal neurodegeneration in a model of multiple sclerosis. Fairless R, Williams SK, Hoffmann DB, Stojic A, Hochmeister S, Schmitz F, Storch MK, Diem R. J Neurosci. 2012 Apr 18;32(16):5585-97. doi: 10.1523/JNEUROSCI.5705-11.2012.

The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. Sundivakkam PC, Freichel M, Singh V, Yuan JP, Vogel SM, Flockerzi V, Malik AB, Tiruppathi C. Mol Pharmacol. 2012 Apr;81(4):510-26. doi: 10.1124/mol.111.074658. 

März

Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel MFlockerzi V, Zheng F. Mol Pharmacol. 2012 Mar;81(3):384-92. doi: 10.1124/mol.111.075341.

Februar

SNARE protein expression and localization in human cytotoxic T lymphocytes. Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig JHoth MEur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915.

EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals. Schmitz F, Natarajan S, Venkatesan JK, Wahl S, Schwarz K, Grabner CP. Front Mol Neurosci. 2012 Feb 29;5:26. doi: 10.3389/fnmol.2012.00026. 

Januar

Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. Samapati R, Yang Y, Yin J, Stoerger C, Arenz C, Dietrich A, Gudermann T, Adam D, Wu S, Freichel MFlockerzi V, Uhlig S, Kuebler WM. Am J Respir Crit Care Med. 2012 Jan 15;185(2):160-70. doi: 10.1164/rccm.201104-0717OC.

Andere

Role of Microglia in the normal brain. Kirchhoff FNeuroglia. 2012 3rd ed. Oxford University Press, New York. Eds. Kettenmann H and Ransom BR, pp 605-613.

TMEM2 proteins are localized in lysosomes and other acidic compartments. Bach A, Kriebs U, Tsvilovskyy V, Wissenbach U, Mannebach S, Scholz A, Flockerzi VWeissgerber PLipp PFreichel MNaunyn-Schmiedeberg’s Arch Pharmacol. 2012 019, Suppl. 1:7.