Ca2+ signals:
Molecular Mechanisms and Integrative Functions Collaborative Research Center 894

News

New project approved for SFB 894.

Martin van der Laan joins the Collaborative Research Center in April 2017.

The German Research Foundation (DFG) has approved a new project for the SFB 894.

From April 2017, Professor Martin van der Laan will explore the "role of MICOS in mitochondrial Ca2 + homeostasis".

Since December 2015, Martin van der Laan has been Professor of Physiological Chemistry at the Saarland University.

We warmly welcome him and look forward to a successful cooperation.

Understanding Intracellular Calcium Signalling


Collaborative Research Center 894

"Ca2+ signals: Molecular Mechanisms und Integrative Functions"

Reception, processing and transfer of information are fundamental to higher organisms.
Among a myriad of signaling molecules, Ca2+ ions stand out. Their concentration in the cytosol of most cells is kept at an extremely low level (≤ 100 nM) allowing small changes in calcium flux to have far reaching effects.

The Collaborative Research Center 894 (Sonderforschungsbereich 894 – CRC/SFB 894) investigates a wide range of Ca2+ signaling, from the molecular mechanisms of their creation to their integrative effects on the whole body. The objective of the CRC 894 is to examine how subcellular Ca2+ signals control the physiological behavior of whole organs. 

The 15 projects analyze the origin and course of elemental Ca2+ signals in the cells of the immune system, the central nervous system, the cardiovascular system, sensory systems and the neuroendocrine system. 

Three platform projects provide techniques and services which are available to all the projects, thus supporting them in realizing their goals.
Furthermore, the platform projects focus on methodological developments in the fields of high resolution microscopy (P1), production and maintenance of transgenic animals (P2) and generation of peptides and antibodies (P3).

CRC 894 is funded by the  German Research Foundation (DFG). 

First funding period: 01.01.2011-31.12.2014
Second funding period: 01.01.2015-31.12.2018