Ca2+ signals:
Molecular Mechanisms and Integrative Functions Collaborative Research Center 894

Project A20 - Martin van der Laan

Role of MICOS in mitochondrial Ca2+ homeostasis

Project A20 (van der Laan) studies the role of the mitochondrial contact site and cristae organizing system (MICOS) in mitochondrial architecture, respiratory activity and Ca2+ uptake using a combination of genetic, biochemical and high resolution imaging tools.

The MICOS complex is required for the formation of crista junctions that connect the highly folded cristae membrane domains to the inner boundary membrane of mitochondria. Pathological alterations of MICOS have been found associated with diabetic cardiomyopathy and hepato-encephalopathy.