Ca2+ signals:
Molecular Mechanisms and Integrative Functions Collaborative Research Center 894

Project A10 - Varsha Pattu & Jens Rettig

Cytotoxic T lymphocyte function in vitro and in vivo

We could show that endocytosis of cytotoxic granules contributes significantly to the killing capacity of cytotoxic T lymphocytes. With the help of lipid bilayer TIRF microscopy we will continue to investigate the molecular mechanism of endocytosis, including the Ca2+ and lipid dependence, on the single granule level.

Furthermore, we will study T cell function in an in vivo model, the anterior chamber of the eye.